Humibid Sprinkle: Full Drug Profile

Humibid Sprinkle - General Information

An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]

Pharmacology of Humibid Sprinkle

Humibid Sprinkle is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.

Humibid Sprinkle for patients

TUSSI-ORGANIDIN® NR* (* Newly Reformulated): Patients should be warned about engaging in activities requiring mental alertness, such as driving a car or operating dangerous machinery. Take as prescribed; do not exceed prescribed dose or frequency. Do not crush or chew extended release tablet. Maintain adequate hydration (2-3l L/d of fluids) unless instructed to restrict fluid intake.

TUSSI-ORGANIDIN® DM NR* (* Newly Reformulated): Patients should be warned not to use this product if they are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the M.O. drug. If patients are uncertain whether a prescription drug contains an MAOI, they should be instructed to consult a health professional before taking such a product.

Humibid Sprinkle Interactions

The use of codeine may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs). The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.

Humibid Sprinkle Contraindications

Hypersensitivity to any of the ingredients. The use of dextromethorphan-containing products are contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs).

Additional information about Humibid Sprinkle

Humibid Sprinkle Indication

Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Mechanism Of Action

Humibid Sprinkle may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.

Food Interactions

Take with a full glass of water.

Generic Name

Guaifenesin

Synonyms

o-Methoxyphenyl glyceryl ether; Methoxypropanediol; Metfenossidiolo; Methphenoxydiol; Metossipropandiolo; Guiaphenesin; Glyceryl guiacolate; Glyceryl guaicolate; Glyceryl guaiacyl ether; Glyceryl guaiacolate ether; Glyceryl guaiacolate; Glyceryl guaiacol ether; Glyceryl guaiacol; Glycerol guaiacolate; Glycero-guaiacol ether; Glycerin monoguaiacol ether; Glycerin guaiacolate

Drug Category

Expectorants

Drug Type

Small Molecule; Approved

Other Brand Names containing Guaifenesin

Actifed-C; Aeronesin; Amonidren; Amonidrin; Anti-Tuss; Aresol; Balminil Expectorant; Benylin-E; Breonesin; Bronchol; Calmipan; Calmylin Expectorant; Colrex expectorant; Cortussin; Creson; Diabetic Tussin EX; Dilyn; Dorassin; Equicol; Fenesin; Flartussin; Gaiamar; Gee-Gee; Genatuss; Glycodex; Glycotuss; Glytuss; Gnaifenesin; Guaia-rom; Guaiacol glycerin ether; Guaiacol glycerol ether; Guaiacol glyceryl ether; Guaiacolglicerinetere; Guaiacuran; Guaiacurane; Guaiacyl glyceryl ether; Guaiamar; Guaianesin; Guaicol glycerine ether; Guaicol glyceryl ether; Guaiphenesin; Guaiphenesine; Guaiphesin; Guajacol-glycerinaether; Guajacuran; Guajamar; Guanar; Guayanesin; Guiatuss; Gvaja; Halotussin; Humibid L.A; Humibid Sprinkle; Hustodil; Hustosil; Hytuss; Hytuss-2X; Mintosyl; Miocaina; Miocurin; Miorelax; Mucinex; Mucostop; Muskurelax; Myocain; Myocaine; Myorelax; Myoscain; Myoscaine; Naldecon Senior EX; Neuroton; Neurotone; Oresol; Oreson; Organidin NR; Pneumomist; Propanosedyl; Reduton; Relaxil G; Relaxyl-G; Reorganin; Resil; Respenyl; Respil; Resyl; Ritussin; Robitussin; Scot-tussin Expectorant; Sinumist-SR; Sirotol; Tenntus; Tenntuss; Tolseron; Tolyn; Touro EX; Tulyl; Tulyn; Uni-tussin;

Absorption

Rapidly absorbed from the GI tract

Toxicity (Overdose)

LD₅₀ 1510 mg/kg (rat, oral)

Biotransformation

Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.

Half Life

1 hour

Dosage Forms of Humibid Sprinkle

Liquid Oral

Chemical IUPAC Name

3-(2-methoxyphenoxy)propane-1,2-diol

Chemical Formula

C10H14O4

Guaifenesin on Wikipedia

https://en.wikipedia.org/wiki/Guaifenesin

Organisms Affected

Humans and other mammals